{"id":2278,"date":"2025-06-04T06:48:56","date_gmt":"2025-06-04T03:48:56","guid":{"rendered":"https:\/\/ckp.icgen.ru\/spf\/?page_id=2278"},"modified":"2025-12-15T06:29:15","modified_gmt":"2025-12-15T03:29:15","slug":"2278-2","status":"publish","type":"page","link":"https:\/\/ckp.icgen.ru\/spf\/?page_id=2278","title":{"rendered":""},"content":{"rendered":"\n<h1 class=\"has-text-align-center\" style=\"font-size:30px\">VRC01<\/h1>\n\n\n\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<div class=\"wp-container-1 wp-block-group\"><div class=\"wp-block-group__inner-container\">\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column is-vertically-aligned-center\">\n<p class=\"has-text-align-left has-small-font-size\"><strong>\u041d\u043e\u043c\u0435\u043d\u043a\u043b\u0430\u0442\u0443\u0440\u043d\u043e\u0435 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435:<\/strong><br><em>B6(Cg)-Igh<sup>tm3.1(VRC01)Nemz<\/sup><\/em><br><strong>\u041a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u0438:<\/strong><br>\u0438\u043d\u0431\u0440\u0435\u0434\u043d\u0430\u044f \u043c\u044b\u0448\u044c;<br>\u0438\u043c\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u0430\u044f \u043c\u044b\u0448\u044c;<br>\u0442\u0440\u0430\u043d\u0441\u0433\u0435\u043d\u043d\u0430\u044f \u043c\u044b\u0448\u044c<br><strong>\u041f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u0435:<\/strong><br>\u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0430 \u0438\u0437 The Jackson Laboratory \u0432 2020<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center\">\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full\"><img loading=\"lazy\" width=\"360\" height=\"300\" src=\"https:\/\/ckp.icgen.ru\/spf\/wp-content\/uploads\/sites\/20\/2025\/06\/VRC.jpg\" alt=\"\" class=\"wp-image-2273\" srcset=\"https:\/\/ckp.icgen.ru\/spf\/wp-content\/uploads\/sites\/20\/2025\/06\/VRC.jpg 360w, https:\/\/ckp.icgen.ru\/spf\/wp-content\/uploads\/sites\/20\/2025\/06\/VRC-300x250.jpg 300w\" sizes=\"(max-width: 360px) 100vw, 360px\" \/><\/figure><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center\">\n<p class=\"has-text-align-right has-small-font-size\"><strong>\u041d\u0430\u043b\u0438\u0447\u0438\u0435:<\/strong><br><strong><em>\u00b7 <\/em><\/strong>\u0432 \u0436\u0438\u0432\u043e\u043c \u0440\u0430\u0437\u0432\u0435\u0434\u0435\u043d\u0438\u0438<br><strong><em>\u00b7 <\/em><\/strong>\u0432 \u0432\u0438\u0434\u0435 \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u043e\u0432<br><strong>\u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u044c:<\/strong><br><strong><em>\u00b7<\/em><\/strong>&nbsp;\u043d\u0430 \u0441\u0432\u043e\u0435\u0439 \u043f\u043b\u043e\u0449\u0430\u0434\u043a\u0435<br><strong><em>\u00b7<\/em><\/strong> \u043d\u0430 \u043f\u043b\u043e\u0449\u0430\u0434\u043a\u0435 \u0426\u041a\u041f<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator\" \/>\n\n\n\n<h4><strong>\u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430<\/strong><\/h4>\n\n\n\n<p>\u0428\u0435\u0440\u0441\u0442\u044c \u0438\u043c\u0435\u0435\u0442 \u0447\u0451\u0440\u043d\u044b\u0439 \u043e\u043a\u0440\u0430\u0441. \u041c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438, \u043c\u0430\u0441\u0441\u0430 \u0442\u0435\u043b\u0430 \u0438 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0433\u043e\u043b\u043e\u0432 \u0432 \u043f\u043e\u043c\u0451\u0442\u0435 \u0438\u0434\u0435\u043d\u0442\u0438\u0447\u043d\u044b \u0442\u0430\u043a\u043e\u0432\u044b\u043c \u0443 \u043c\u044b\u0448\u0435\u0439 \u043b\u0438\u043d\u0438\u0438 <strong>B6<\/strong>. \u0421\u043f\u043e\u0441\u043e\u0431\u043d\u044b \u043a \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u0442\u044f\u0436\u0451\u043b\u043e\u0439 \u0446\u0435\u043f\u0438 \u0448\u0438\u0440\u043e\u043a\u043e \u043d\u0435\u0439\u0442\u0440\u0430\u043b\u0438\u0437\u0443\u044e\u0449\u0435\u0433\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0412\u0418\u0427 <em>VRC01<\/em>, \u043a\u043e\u0442\u043e\u0440\u043e\u0435 \u0440\u0430\u0441\u043f\u043e\u0437\u043d\u0430\u0435\u0442 \u043e\u0431\u043b\u0430\u0441\u0442\u044c \u0433\u043b\u0438\u043a\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430 \u0432\u0438\u0440\u0443\u0441\u043d\u043e\u0439 \u043e\u0431\u043e\u043b\u043e\u0447\u043a\u0438 \u0412\u0418\u0427 (<em>Env<\/em>) \u0438 \u0441\u043e\u0445\u0440\u0430\u043d\u044f\u0435\u0442 \u0441\u043f\u043e\u0441\u043e\u0431\u043d\u043e\u0441\u0442\u044c \u0441\u043f\u0430\u0440\u0438\u0432\u0430\u0442\u044c\u0441\u044f \u0441 \u043d\u0430\u0442\u0438\u0432\u043d\u044b\u043c\u0438 \u043c\u044b\u0448\u0438\u043d\u044b\u043c\u0438 \u0446\u0435\u043f\u044f\u043c\u0438 <em>IgL<\/em>.<\/p>\n\n\n\n<h4><strong>\u0412\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0438\u0441\u043f\u043e\u043b\u044c\u0437\u043e\u0432\u0430\u043d\u0438\u044f<\/strong><\/h4>\n\n\n\n<p>\u0418\u0437\u0443\u0447\u0435\u043d\u0438\u0435 \u0432\u043b\u0438\u044f\u043d\u0438\u044f \u0432\u0430\u043a\u0446\u0438\u043d-\u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0445 \u0448\u0438\u0440\u043e\u043a\u043e \u043d\u0435\u0439\u0442\u0440\u0430\u043b\u0438\u0437\u0443\u044e\u0449\u0438\u0445 \u0430\u043d\u0442\u0438\u0442\u0435\u043b (<strong>bnAbs<\/strong>) \u043d\u0430 \u0412\u0418\u0427-\u0438\u043d\u0444\u0435\u043a\u0446\u0438\u044e; \u0438\u043d\u044b\u0435 \u0438\u043c\u043c\u0443\u043d\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438 \u0432\u0438\u0440\u0443\u0441\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f; \u0440\u0430\u0437\u0440\u0430\u0431\u043e\u0442\u043a\u0430 \u0432\u0430\u043a\u0446\u0438\u043d.<\/p>\n\n\n\n<h4><strong>\u0418\u0441\u0442\u043e\u0440\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0441\u043f\u0440\u0430\u0432\u043a\u0430<\/strong><\/h4>\n\n\n\n<p>\u0414\u0430\u043d\u043d\u0430\u044f \u043b\u0438\u043d\u0438\u044f \u0431\u044b\u043b\u0430 \u0441\u043e\u0437\u0434\u0430\u043d\u0430 \u0432 \u043b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u0438 <strong>The Scripps Research Institute<\/strong> \u0432 2015 \u0433\u043e\u0434\u0443 \u0438 \u043f\u0435\u0440\u0435\u0434\u0430\u043d\u0430 \u0432 <strong>The Jackson Laboratory<\/strong> \u0432 2016 \u0433\u043e\u0434\u0443. \u0412 2020 \u0433\u043e\u0434\u0443 \u043b\u0438\u043d\u0438\u044f \u043f\u043e\u0441\u0442\u0443\u043f\u0438\u043b\u0430 \u0438\u0437 <strong>The Jackson Laboratory<\/strong> \u0432 \u0426\u0435\u043d\u0442\u0440 \u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0440\u0435\u0441\u0443\u0440\u0441\u043e\u0432 \u0418\u0426\u0438\u0413 \u0421\u041e \u0420\u0410\u041d.<\/p>\n\n\n\n<h4><strong>\u041a\u043e\u043d\u0442\u0440\u043e\u043b\u044c \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f<\/strong><\/h4>\n\n\n\n<p>SPF-\u0441\u0442\u0430\u0442\u0443\u0441 \u0441 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u0435\u043c \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u043e\u0432 \u0432 \u0441\u043e\u043e\u0442\u0432\u0435\u0442\u0441\u0442\u0432\u0438\u0438 \u0441 Felasa 2014.<\/p>\n\n\n\n<h4><strong>\u041f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438<\/strong><\/h4>\n\n\n\n<p>1. Joseph G Jardine et al. <em>Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen<\/em> \/\/ Science. 2015 Jun 18;349(6244):156\u2013161.<br><a href=\"10.1126\/science.aac5894\">doi: 10.1126\/science.aac5894<\/a><\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>VRC01 \u041d\u043e\u043c\u0435\u043d\u043a\u043b\u0430\u0442\u0443\u0440\u043d\u043e\u0435 \u043d\u0430\u0437\u0432\u0430\u043d\u0438\u0435:B6(Cg)-Ightm3.1(VRC01)Nemz\u041a\u0430\u0442\u0435\u0433\u043e\u0440\u0438\u0438:\u0438\u043d\u0431\u0440\u0435\u0434\u043d\u0430\u044f \u043c\u044b\u0448\u044c;\u0438\u043c\u043c\u0443\u043d\u043e\u0434\u0435\u0444\u0438\u0446\u0438\u0442\u043d\u0430\u044f \u043c\u044b\u0448\u044c;\u0442\u0440\u0430\u043d\u0441\u0433\u0435\u043d\u043d\u0430\u044f \u043c\u044b\u0448\u044c\u041f\u0440\u043e\u0438\u0441\u0445\u043e\u0436\u0434\u0435\u043d\u0438\u0435:\u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0430 \u0438\u0437 The Jackson Laboratory \u0432 2020 \u041d\u0430\u043b\u0438\u0447\u0438\u0435:\u00b7 \u0432 \u0436\u0438\u0432\u043e\u043c \u0440\u0430\u0437\u0432\u0435\u0434\u0435\u043d\u0438\u0438\u00b7 \u0432 \u0432\u0438\u0434\u0435 \u044d\u043c\u0431\u0440\u0438\u043e\u043d\u043e\u0432\u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e\u0441\u0442\u044c:\u00b7&nbsp;\u043d\u0430 \u0441\u0432\u043e\u0435\u0439 \u043f\u043b\u043e\u0449\u0430\u0434\u043a\u0435\u00b7 \u043d\u0430 \u043f\u043b\u043e\u0449\u0430\u0434\u043a\u0435 \u0426\u041a\u041f \u0425\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0438\u0441\u0442\u0438\u043a\u0430 \u0428\u0435\u0440\u0441\u0442\u044c \u0438\u043c\u0435\u0435\u0442 \u0447\u0451\u0440\u043d\u044b\u0439 \u043e\u043a\u0440\u0430\u0441. \u041c\u043e\u0440\u0444\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u0437\u043d\u0430\u043a\u0438, \u043c\u0430\u0441\u0441\u0430 \u0442\u0435\u043b\u0430 \u0438 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u043e \u0433\u043e\u043b\u043e\u0432 \u0432 \u043f\u043e\u043c\u0451\u0442\u0435 \u0438\u0434\u0435\u043d\u0442\u0438\u0447\u043d\u044b \u0442\u0430\u043a\u043e\u0432\u044b\u043c \u0443 \u043c\u044b\u0448\u0435\u0439 \u043b\u0438\u043d\u0438\u0438 B6. \u0421\u043f\u043e\u0441\u043e\u0431\u043d\u044b \u043a \u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0438 \u0442\u044f\u0436\u0451\u043b\u043e\u0439 \u0446\u0435\u043f\u0438 \u0448\u0438\u0440\u043e\u043a\u043e \u043d\u0435\u0439\u0442\u0440\u0430\u043b\u0438\u0437\u0443\u044e\u0449\u0435\u0433\u043e \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430 \u043a \u0412\u0418\u0427 VRC01, [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/pages\/2278"}],"collection":[{"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2278"}],"version-history":[{"count":5,"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/pages\/2278\/revisions"}],"predecessor-version":[{"id":2635,"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=\/wp\/v2\/pages\/2278\/revisions\/2635"}],"wp:attachment":[{"href":"https:\/\/ckp.icgen.ru\/spf\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}